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The "two-headed" peptide inhibitors of interleukin-1 action.
Autorzy
Rok wydania
2000
Czasopismo
Numer woluminu
21
Strony
1411-1420
DOI
10.1016/s0196-9781(00)00285-0
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Two peptide fragments of IL-1 family proteins, ITGSE and VTKFYF compete with IL-1 for the cellular receptor. We synthesized a series of peptides composed of the sequences ITGSE and VTKFYK bound directly to each other or connected by such linkers as (Gly)(n), L- and D-Pro residues, Glu and Lys residues (with peptide bond formed by main amino and carboxy groups or by side chain groups), and beta-alanine and its homologues. Peptide IX with a gamma-Glu linker was the most potent inhibitor of IL-1 action. It was twice as potent as both of the peptides indicated.
Adres publiczny
https://doi.org/10.1016/s0196-9781(00)00285-0
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