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Inne
Structural aspects of copper(II) binding by a multi-His analogue of somatostatin.
Autorzy
Rok wydania
2014
Czasopismo
Numer woluminu
416
Strony
57-62
DOI
10.1016/j.ica.2014.03.020
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
In this paper we present the studies on coordination abilities of multi-His analogue of somatostatin. The somatostatin is a peptide hormone of which radionuclide-labeled analogues are successfully used in clinical practice in receptor scintigraphy. Its the analogue presented in this study is characterized by the presence of four His residues located in groups of two at both ends of the peptide. The -PheTrpLysThr- fragment placed between His residues is responsible for the spatial arrangement which determines the interaction with somatostatin receptors. In this paper we present the impact of copper ion binding on the spatial arrangement of the crucial fragment of peptide. The analysis of potentiometric and spectroscopic data allowed us to characterize the coordination abilities of the peptide and show that the ligand forms a {4×NIm} complex in the physiological range of pH. Results of the molecular modeling gave an insight into the structural aspects of this complex.
Słowa kluczowe
Somatostatin, Copper, Histidine, Potentiometric measurements, Spectroscopic studies, Coordination
Adres publiczny
http://dx.doi.org/10.1016/j.ica.2014.03.020
Strona internetowa wydawcy
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