Wydział Chemii

Nishithendu Bikash Nandi

Atanu Purkayastha

Julia Kłak

Rakesh Ganguly

Susanta Ghanta

Tarun Kumar Misra

2022

Journal of Molecular Structure

1252

132164/1-132164/10

10.1016/j.molstruc.2021.132164

Naukowa

Angielski

Artykuł

Two new monomeric copper(II) complexes based on 1,3-dimethyl-5-(4′/3′-pyridylazo)-6-aminouracil (HL1: 4′-pyridylazo, complex 1: cis-Cu^IIL1₂.MeOH; HL2: 3′-pyridylazo, complex 2: cis-Cu^IIL1₂.H₂O) were synthesized, characterized and investigated for redox, magnetic and protein-binding properties. The complex 1 is in monoclinic space group C2/c, Z = 4 whereas the complex 2 is in triclinic space group P-1, Z = 2. The complexes hold similar structure in solid and solution state as could be infered from the EPR spectra of 1 having well-resolved hyperfine features, g_|| > g_┴ > g_e (g_|| =2.20 and g_┴ =2.05). The E_½ values for oxidative response of Cu(III)/Cu(II) couple are 1.030 V (ΔE = 133 mV) for 1 and 0.982 V (ΔE = 128 mV) for 2, indicating high redox stability of Cu(II) ions in the complex environment. Direct current (DC) variable-temperature magnetic susceptibility measurements on polycrystalline sample of 1 were carried out in the temperature range 1.8-300 K. The magnetic behavior indicates a weak antiferromagnetic interaction between Cu(II) ions in the crystal lattice below 25 K. The study of Bovin Serum Albumin (BSA)-complex interactions reveals that the BSA binds the complexes through the sites of tryptophan residues in 1:1 manner (n = 0.9007 & K_A = 1.482 × 10⁴M⁻¹ for 1 and 0.7433 & K_A =2.394×10³M⁻¹ for 2). Thus, the developed complexes could be treated as muti-functional materials.

6-Aminoazouracil, Mononuclear copper(II), Weak antiferromagnetic coupling, Protein-complex interactions

http://dx.doi.org/10.1016/j.molstruc.2021.132164

http://www.elsevier.com