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Inne
Pneumococcal HxxHxH triad - Copper(II) interactions - How important is the 'x'?
Autorzy
Rok wydania
2019
Czasopismo
Numer woluminu
488
Strony
255-259
DOI
10.1016/j.ica.2019.01.029
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
PhtA, a Streptococcus pneumoniae polyhistidine triad protein, which contributes to virulence by interacting with components of the immune system, by being involved in adherence of bacteria and in Zn(II) uptake, contains five copies of the HxxHxH sequence. Since this motif is also present in numerous Cu(II) binding proteins, we decided to focus on the bioinorganic chemistry of copper(II) with three of such PhtA repeats, in order to understand which of the PhtA triads binds Cu(II) with the highest affinity and explain if Cu(II) would be able to outcompete Zn(II) from its native binding site under physiological metal concentrations.
Adres publiczny
https://doi.org/10.1016/j.ica.2019.01.029