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Inne
Sensitive detection of charge derivatized peptides at the attomole level using nano-LC-ESI-MRM analysis.
Autorzy
Rok wydania
2014
Czasopismo
International Journal of Mass Spectrometry
Numer woluminu
362
Strony
32-38
DOI
10.1016/j.ijms.2014.02.018
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The detection sensitivity of peptides in the form of quaternary ammonium salts at the N-terminus was analyzed using liquid chromatography/electrospray ionization tandem mass spectrometry. The derivatization, efficiently prepared by the solid phase synthesis, achieved subfemtomole to attomole levels of peptide detection by measurement in the multiple reaction monitoring mode. The presented methodology creates a new possibility for analysis of trace amounts of peptides and other compounds.
Słowa kluczowe
Detection sensitivity, Ionization tag, quaternary ammonium salts, LC-ESI-MS/MS, MRM
Adres publiczny
http://dx.doi.org/10.1016/j.ijms.2014.02.018
Strona internetowa wydawcy
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