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Inne
Dicationic ruthenium(II)–arene–curcumin complexes containing methylated 1,3,5–triaza-7-phosphaadamantane : synthesis, structure, and cytotoxicity.
Autorzy
Rok wydania
2017
Czasopismo
European Journal of Inorganic Chemistry
Strony
2905-2910
DOI
10.1002/ejic.201700183
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Dicationic ruthenium(II)–p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the first time. The solid-state structure of [Ru(p-cym)(curc)(PTA-Me)][SO3CF3][BF4] has also been determined by single-crystal X-ray diffraction. Modest antiproliferative activities of the complexes were observed against cisplatin-sensitive and cisplatin-resistant human ovarian carcinoma cells (A2780 and A2780cisR, respectively) and nontumorigenic human embryonic kidney (HEK293) cells.
Słowa kluczowe
Curcumin, Bisdemethoxycurcumin, Arene ligand, ruthenium, cytotoxicity, Antitumor agents
Adres publiczny
http://dx.doi.org/10.1002/ejic.201700183
Strona internetowa wydawcy
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