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Inne
Ruthenium(II) piano stool coordination compounds with aminomethylphosphanes : synthesis, characterisation and preliminary biological study in vitro.
Autorzy
Rok wydania
2017
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
170
Strony
178-187
DOI
10.1016/j.jinorgbio.2017.02.017
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Reaction of {[Ru(η6-p-cymene)Cl]2(μ-Cl)2} (1) with aminomethylphosphane derived from morpholine (P{CH2N(CH2CH2)2O}3 (A), PPh2{CH2N(CH2CH2)2O} (B)) or piperazine (P{CH2N(CH2CH2)2NCH2CH3}3 (C), PPh2{CH2N(CH2CH2)2NCH2CH3} (D)) results in four new piano stool ruthenium(II) coordination compounds: [Ru(η6-p-cymene)Cl2(A)] (2A), [Ru(η6-p-cymene)Cl2(B)] (2B), [Ru(η6-p-cymene)Cl2(C)] (2C) and [Ru(η6-p-cymene)Cl2(D)] (2D). Every complex was fully characterized using spectroscopic methods (1H, 13C{1H}, 31P{1H} NMR and ESI-MS), elemental analysis, X-ray single crystal diffraction and DFT calculations. Preliminary studies of in vitro cytotoxicity on the A549 (human lung adenocarcinoma) and MCF7 (human breast adenocarcinoma) cell lines revealed 2A-2D activity in the same order of magnitude as in the case of cisplatin. Additionally, the study confirmed the ability of 2A-2D to interact with DNA helix and transferrin.
Słowa kluczowe
aminomethylphosphanes, cytotoxicity, organometallic chemistry, ruthenium
Adres publiczny
http://dx.doi.org/10.1016/j.jinorgbio.2017.02.017
Strona internetowa wydawcy
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