Repozytorium
Wyszukaj
Kolekcje
Inne
Aminopropyltriethoxysilane (APTES)-Modified Nanohydroxyapatite (nHAp) Incorporated with Iron Oxide (IO) Nanoparticles Promotes Early Osteogenesis, Reduces Inflammation and Inhibits Osteoclast Activity
Autorzy
Rok wydania
2022
Czasopismo
Numer woluminu
15
Strony
2095/1-2095/31
DOI
10.3390/ma15062095
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Due to its increased prevalence, osteoporosis (OP) represents a great challenge to health care systems and brings an economic burden. To overcome these issues, treatment plans that suit the need of patients should be developed. One of the approaches focuses on the fabrication of personalized biomaterials, which can restore the balance and homeostasis of disease-affected bone. In the presented study, we fabricated nanometer crystalline hydroxyapatite (nHAp) and iron oxide (IO) nanoparticles stabilized with APTES and investigated whether they can modulate bone cell metabolism and be useful in the fabrication of personalized materials for OP patients. Using a wide range of molecular techniques, we have shown that obtained nHAp@APTES promotes viability and RUNX-2 expression in osteoblasts, as well as reducing activity of critical proinflammatory cytokines while inhibiting osteoclast activity. Materials with APTES modified with nHAp incorporated with IO nanoparticles can be applied to support the healing of osteoporotic bone fractures as they enhance metabolic activity of osteoblasts and diminish osteoclasts’ metabolism and inflammation.
Słowa kluczowe
osteoporosis, osteoblasts, osteoclasts, hydroxyapatite, APTES, iron oxides
Licencja otwartego dostępu
Licencja na prawach której można swobodnie kopiować, rozprowadzać, zmieniać i remiksować objęty prawem autorskim utwór (Utwór-przedmiot prawa autorskiego) pod warunkiem podania imienia i nazwiska autora utworu pierwotnego oraz źródła pochodzenia utworu.
Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode
Adres publiczny
http://dx.doi.org/10.3390/ma15062095
Strona internetowa wydawcy
Podobne publikacje
Nanohydroxyapatite (nHAp) doped with iron oxide nanoparticles (IO), miR-21 and miR-124 under magnetic field conditions modulates osteoblast viability, reduces inflammation and inhibits the growth of osteoclast – A novel concept for osteoporosis treatment: Part 1.
Marycz Krzysztof, Smieszek Agnieszka, Marcinkowska Klaudia, Sikora Mateusz, Turlej Eliza, Sobierajska Paulina, Patej Adrian, Bieńko Alina, Wiglusz Rafał J.
Strontium-doped organic-inorganic hybrids towards three-dimensional scaffolds for osteogenic cells.
John Łukasz, Podgórska Marta, Nedelec Jean-Marie, Cwynar-Zając Łucja, Dzięgiel Piotr
Modern stereoselective synthesis of chiral sulfinyl compounds.
Wojaczyńska Elżbieta, Wojaczyński Jacek