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The new hypothesis on amino acid complementarity and its experimental proof.
Autorzy
Rok wydania
1998
Czasopismo
Numer woluminu
5
Strony
329-331
DOI
10.1007/BF02443480
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
During our work on the periodicity of the genetic code we proposed a new scheme of amino acid pairing [Siemion, I.Z. and Stefanowicz, P., Biosystems, 27 (1992) 77; Bull. Pol. Acad. Sci., 40 (1992) 11]. Based on this scheme, we designed and synthesized the sequences IIYTLC(Acm)GLYL (II), IIYPLC(Acm)GLYL (V), and IYPLC(Acm)GLY (VI), which are 'antipeptides' with respect to immunoactive fragments of TGFfi2: YIGKTPKI (III) and YYIGKTPKIE (IV). The peptide-antipeptide interaction was investigated by electrospray ionization mass
spectrometry and circular dichroism methods. The results obtained indicate that peptides interact selectively with 'antipeptides'.
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