Repozytorium

Copper(I) complexes with phosphines P(p-OCH3-Ph)2CH2OH and P(p-OCH3-Ph)2CH2SarGly : synthesis, multimodal DNA interactions, and prooxidative and in vitro antiproliferative activity.

Autorzy

Urszula K. Komarnicka

Sandra Kozieł

Piotr Zabierowski

Rafał Kruszyński

Monika K. Lesiów

Francesco Tisato

Marina Porchia

Agnieszka Kyzioł

Rok wydania

2020

Czasopismo

Journal of Inorganic Biochemistry

Numer woluminu

203

Strony

110926/1-110926/14

DOI

10.1016/j.jinorgbio.2019.110926

Kolekcja

Naukowa

Język

Angielski

Typ publikacji

Artykuł

Streszczenie

Phosphonium salt (p-OCH3-Ph)2P(CH2OH)2Cl (MPOHC), derived phosphine ligands without and with SarGly (Sarcosine-Glycine) peptide carrier P(p-OCH3-Ph)2CH2OH (MPOH) and P(p-OCH3-Ph)2CH2SarGly (MPSG), respectively, and two copper(I) complexes [Cu(I)(dmp)(MPOH)] (1-MPOH; dmp = (2,9-dimethyl-1,10-phenanthroline)) and [Cu(I)(dmp)(MPSG)] (1-MPSG) were synthesized. The resulting compounds were characterized by elemental analysis, 1D and 2D NMR and UV–Vis absorption spectroscopies, mass spectrometry, cyclic voltammetry and by X-ray diffraction analysis. Cytotoxicity of all compounds was evaluated in vitro against colon, lung, breast, pancreatic, prostate tumor cell lines, as well as towards non-tumor cell lines: lung, kidney and keratinocyte. Stable in biological medium in the presence of atmospheric oxygen, Cu(I) complexes exerted a cytotoxic effect higher than that elicited by cisplatin against tested cancer cell lines. The introduction of methoxy group onto the phenyl rings of the phosphine ligand coordinated to the copper(I) ion resulted in a relevant increase of cytotoxicity in the case of breast, pancreatic and prostate tumor cell lines in vitro. Attachment of a peptide carrier significantly increased the selectivity towards cancer cells. Fluorescence spectroscopic data (calf thymus DNA: CT-DNA) titration), together with analysis of DNA fragmentation (gel electrophoresis) and molecular docking provided evidence for the multimodal interaction of copper compounds with DNA and showed their unusual low genotoxicity. Additionally, copper complexes were able to generate reactive oxygen species as a result of redox processes, proved by fluorescence spectroscopy and cyclic voltamperometry.

Słowa kluczowe

Copper(I) complexes, Phosphine, Peptide, Cancer, DNA

Adres publiczny

http://dx.doi.org/10.1016/j.jinorgbio.2019.110926

Strona internetowa wydawcy

http://www.elsevier.com

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