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Synthesis of unsymmetrical 2,6-diarylanilines by palladium-catalyzed C–H bond functionalization methodology.
Autorzy
Rok wydania
2018
Czasopismo
Numer woluminu
83
Strony
5844-5850
DOI
10.1021/acs.joc.8b00659
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
3,5-Dimethylpyrazole was employed as a monodentate directing group for palladium-catalyzed ortho-sp2 C–H arylation with aryl iodides. The reaction shows good functional group tolerance and outstanding selectivity for mono-ortho-arylation. Ozonolysis of ortho-arylated arylpyrazoles gave acylated biphenylamines that were further arylated to afford unsymmetrically substituted 2,6-diarylacetanilides.
Adres publiczny
http://dx.doi.org/10.1021/acs.joc.8b00659
Strona internetowa wydawcy
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