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RGD peptides.
Autorzy
Redaktorzy
Rok wydania
2013
Wydawca
Academic Press is an imprint of Elsevier
Miejsce wydania
San Diego
Strony
705-713
DOI
10.1016/B978-0-12-385095-9.00095-6
Tytuł książki
Handbook of biologically active peptides. - 2nd ed.
ISBN
978-0-12-385095-9
Kolekcja
Język
Angielski
Typ publikacji
Rozdział książki
Peptides containing the RGD (Arg–Gly–Asp) motif and their molecular mimetics bind integrin receptors with high affinity and inhibit cell adhesion by competing with the integrins/matrix inter-action leading to anti-inflammatory, anticoagulant, antimetastatic, and antiangiogenic effects. RGD peptides are also involved in bacterial pathogen invasion, tumor and endothelial cell-targeting via the integrin receptors as well as in noninvasive tumor imag-ing, targeting, and radiation treatment. This review presents various functions of RGD peptides and perspectives of their application as potential drugs.
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