Wydział Chemii

Patrycja Zawilska

Katarzyna Cieślik-Boczula

2017

Biophysical Chemistry

221

1-9

10.1016/j.bpc.2016.11.004

Naukowa

Angielski

Artykuł

Long-chain alkylresorcinols (ARs) are commonly found in plant and bacteria cells, and they exhibit a wide variety of biological effects, including antifungal, antitumor, and antiphrastic activities. The cholesterol (Chol)-like effect of ARs with hydrocarbon side-chain lengths ranging from C15 to C25 on the structure of pure and Chol-doped dipalmitoylphosphocholine (DPPC) and sphingomyelin (SM) membranes was investigated by Laurdan fluorescence spectroscopy. The Laurdan emission generalized polarization parameter was analyzed as a function of the temperature and excitation wavelength in DPPC (or SM)/Chol, DPPC (or SM)/AR, and DPPC/Chol/AR systems. It was found that AR incorporation into both DPPC and SM bilayers induces an increase in the temperature of the main lipid phase transition, similar to the effect of Chol molecule incorporation. The phase separation, lipid-chain ordering, and membrane hydration are discussed for the AR-mixed membranes and compared with DPPC (or SM)/Chol membranes.

Laurdan fluorescence, DPPC membranes, Sphingomyelin (SM), Cholesterol, Long chain alkylresorcinols, Lipid main phase transition, hydration of lipid membrane, Lipid chain order

http://dx.doi.org/10.1016/j.bpc.2016.11.004

http://www.elsevier.com