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Design and functionalization of bioactive benzoxazines : an unexpected ortho-substitution effect.
Autorzy
Rok wydania
2019
Czasopismo
Numer woluminu
43
Strony
12042-12053
DOI
10.1039/c8nj06440g
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A family of o, p- and N-functionalized dihydro-2H-benzo-1,3-oxazines was synthesized and characterized. In vitro antimicrobial activity of the new benzoxazines was assessed against pathogenic fungi and Gramnegative and Gram-positive bacteria. The screened compounds showed significant in vitro antimicrobial effect, but introduction of the bulky substituent in the ortho position of the aryl ring caused a loss of their antibacterial efficacy. Cytotoxic assay results revealed that a molecule containing long alkyl chain substituents offered a remarkable viability of mouse fibroblast cells. Additionally, the liquid nature of alkylchain-modified monomers and the high processing windows indicate their high application potential.
Adres publiczny
http://dx.doi.org/10.1039/c8nj06440g
Strona internetowa wydawcy
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