Repozytorium
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Inne
Manganese binding to antioxidant peptides involved in extreme radiation resistance in Deinococcus radiodurans.
Autorzy
Rok wydania
2016
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
164
Strony
49-58
DOI
10.1016/j.jinorgbio.2016.08.012
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A decapeptide, DEHGTAVMLK (DP1), and its random scrambled version, THMVLAKGED (DP2), have been studied for their interactions with manganese. The amino acid composition of the peptides was selected to include the majority of the most prevalent amino acids present in a Deinococcus radiodurans bacterium cell-free extract that contains components capable of conferring extreme resistance to ionizing radiation. The extract appears to be rich in Mn(II) complexes which seem to be responsible for protecting proteins from Reactive Oxygen Species damage. We focused our attention on the interaction of the decapeptides with Mn(II) ion with the aim of obtaining information on the possible complexes formed, by using NMR, EPR, and ESI-MS techniques.
Słowa kluczowe
manganese, Peptides, Radiation resistance, Deinococcus radiodurans
Adres publiczny
http://dx.doi.org/10.1016/j.jinorgbio.2016.08.012
Strona internetowa wydawcy
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