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Inne
Synthesis and pharmacological screening of derivatives of isoxazolo[4,3-d] pyrimidine and isoxazolo[4,5-d]pyrimidine.
Autorzy
Rok wydania
2010
Czasopismo
Journal of Heterocyclic Chemistry
Numer woluminu
47
Strony
677-682
DOI
10.1002/jhet.373
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A number of derivatives of isoxazolo[4,3‐d]pyrimidine and isoxazolo[4,5‐d]pyrimidine were prepared with potential anticancer activity. Condensation of 4‐amino‐5‐benzoyl‐isoxazolo‐3‐carboxylic acid hydrazide with ethyl orthoformate and then with different amines gave a series of 3‐benzoyl‐7‐oxo‐7H‐isoxazolo[4,3‐d]pyrimidin‐6‐yl‐aryliden‐formamidine. A series of 5‐aminomethyl‐7‐phenyl‐isoxazolo[4,5‐d]pyrimidine‐3‐carboxamide was obtained from 4‐amino‐5‐benzoylisoxazole‐3‐carboxamide with acetonitrile, and chloroacetonitrile with gaseous hydrogen chloride. Some of these compounds were tested for their cytotoxic activity.
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