Wydział Chemii

K. Kochman

A. Gajewska

Henryk Kozłowski

E. Masiukiewicz

B. Rzeszotarska

1992

Journal of Inorganic Biochemistry

48

41-46

10.1016/0162-0134(92)80051-v

Naukowa

Angielski

Artykuł

The effect of Cu²⁺, Ni²⁺, Zn²⁺ and their complexes with LHRH on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) was estimated in in vivo experiments with the use of the method proposed by Ramirez and McCann. Ovariectomized, estradiol, and progesterone pretreated rats were injected intraveneously either with LHRH alone, a metal ion alone, a mixture of metal and hormone, or a metal-LHRH complex. A metal alone or a mixture of it with LHRH did not affect gonadotropin release at all or no more than LHRH alone. However, the complex of Cu²⁺ with LHRH brought about a high release of LH and even higher release of FSH. This indicates that copper complex is more effective than metal-free LHRH. The nickel complex showed a similar although lesser effect. The zinc complex had similar potency to free LHRH though higher FSH-releasing ability was noticed. We conclude that copper-, nickel-, and zinc-LHRH complexes were more potent than the peptide hormone itself and promoted the FSH release in the ovariectomized, estradiol, and progesterone pretreated rats.

http://doi.org/10.1016/0162-0134(92)80051-v

http://www.elsevier.com