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2-(Hydroxyimino)propanohydroxamic acid, a new effective ligand for aluminium.
Autorzy
Rok wydania
2000
Czasopismo
Journal of the Chemical Society, Dalton Transactions
Strony
4201-4208
DOI
10.1039/B004432F
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The capacity of a new ligand, 2-(hydroxyimino)propanohydroxamic acid (HPH, an analog of alanine), to bind theAl3 ion has been examined. A particular objective was to check whether the HPH oximic group could take part inaluminum co-ordination together with the two hydroxamic oxygens, a possibility that could make HPH an efficientlow-molecular-mass ligand for detrimental Al3 ions in vivo. Glass electrode potentiometry, NMR spectroscopy andElectrospray Mass Spectrometry were used to investigate Al3–HPH complex equilibria and their related structuralaspects. The aluminium binding capacity of HPH was compared to that of other monohydroxamic acids. In spite ofthe lowest basicity of its hydroxamic moiety and the non-involvement of its oximic moiety in metal ion binding, HPHwas found to be a very competitive ligand. Comparative quantum calculations performed on the systems involvedsuggest that electrostatic interactions induced by the ligand molecule are determining for complex stability
Adres publiczny
DOI https://doi.org/10.1039/B004432F
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