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Inne
Structural aspects of dehydration and rehydration in the adenosine 5′-diphosphate (ADP)–potassium–water system
Autorzy
Rok wydania
2023
Czasopismo
Numer woluminu
25
Strony
4592-4603
DOI
10.1039/d3ce00395g
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
This work presents the solution crystallization, post-crystallization dehydration and structural studies of hydrated and anhydrous potassium salts of adenosine 5′-diphosphate obtained in this way. ADP is crucial for cellular energy processes. K+ is the most abundant metal cation in cells. However, both ADP and nucleotide–K systems are poorly understood in terms of crystal structure. We report three hydrated salts: K(ADP)·4H2O, K(ADP)·2H2O, and (H5O2)K(ADP)2·4.25H2O and one anhydrous salt, K(ADP), formed by dehydration of K(ADP)·2H2O, proceeding as a single crystal to single crystal (SC-to-SC) process, which were tested by single crystal XRD, variable temperature micro-PXRD and TGA/DTA methods. The phase transition in (H5O2)K(ADP)2·4.25H2O was observed. The structural description of the dehydration–rehydration process in the ADP–potassium–water system was presented. The most important interaction types and structural motifs as well as the function of water molecules in the studied ADP crystals were identified.
Adres publiczny
http://dx.doi.org/10.1039/d3ce00395g