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Unusual gain in the coordination ability of vasopressin-like peptides towards Cu2+ ions by insertion of the highly hydrophobic side chain.
Autorzy
Rok wydania
2003
Czasopismo
Numer woluminu
27
Strony
251-256
DOI
10.1039/B206790K
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Potentiometric and spectroscopic data show an unusual gain in the stability constants of Cu2+ complexes with vasopressin analogues having the highly hydrophobic naphthalene-alanine residue inserted in position three (Nal3). The naphthalene derivative is a much more powerful ligand for binding Cu2+ ions that the parent peptide. Theoretical calculations indicate the effective hydrophobic protection of the metal site by Tyr2 and Nal3 aromatic side-chains. The interaction of the guanidine moiety of Arg4 with naphthalene can also increase distinctly the stability of the respective 4N complex.
Adres publiczny
https://doi.org/10.1039/B206790K
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