Repozytorium

Chiral 2 + 3 keto-enamine pseudocyclophanes derived from 1,3,5-triformylphloroglucinol.

Autorzy

P. Kieryk

Jan Janczak

Jarosław Panek

Marcin Miklitz

Jerzy Lisowski

Rok wydania

2016

Czasopismo

Organic Letters

Numer woluminu

18

Strony

12-15

DOI

10.1021/acs.orglett.5b02989

Kolekcja

Naukowa

Język

Angielski

Typ publikacji

Artykuł

Streszczenie

The reactions of 1,3,5-triformylphloroglucinol with (1R,2R)-1,2-diaminocyclohexane, (1R,2R)-1,2-diphenylethylenediamine, or (R)-2,2′-diamino-1,1′-binaphthyl result in the formation of enantiopure [2 + 3] keto-enamine condensation products, in contrast to analogous reactions of 1,3,5-triformylbenzene, where [4 + 6] Schiff base cages are formed. The X-ray crystal structure of the diaminocyclohexane 2 + 3 derivative as well as modeled structures of other compounds of this type show cyclophane-like molecules with close contact between the phloroglucinol rings. Density Functional Theory (DFT) calculations confirm that there is a sizable π-π interaction between these rings influencing the conformation of these molecules.

Adres publiczny

http://dx.doi.org/10.1021/acs.orglett.5b02989

Strona internetowa wydawcy

https://www.acs.org/content/acs/en.html

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