Wydział Chemii

Aleksandra Tesmar

Dariusz Wyrzykowski

Katarzyna Kazimierczuk

Julia Kłak

Szymon Kowalski

Iwona Inkielewicz-Stępniak

Joanna Drzeżdżon

Dagmara Jacewicz

Lech Chmurzyński

2017

Zeitschrift für Anorganische und Allgemeine Chemie

643

501-510

10.1002/zaac.201700022

Naukowa

Angielski

Artykuł

The crystal structure of a nitrilotriacetate (nta) oxidovanadium(IV) salt with 4-methylpyridinium cation, [4-Me(Py)H]⁺, of [4-Me(Py)H][VO(nta)(H₂O)] stoichiometry was determined. The complex comprises a discrete mononuclear [VO(nta)(H₂O)]^– coordination entity that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The complex was characterized by spectroscopic (IR and EPR) methods, magnetic measurements, and thermogravimetry (TG-FTIR). The stability of the title compound in aqueous solutions was investigated by using the potentiometric titration method. Furthermore, spectrophotometric (UV/Vis) studies have revealed that the compound is capable to scavenge the superoxide free radicals (O₂^•–) as well as stable organic radicals i.e. 2,2′-azinobis(3-ethylbenzothiazoline-6 sulfonic acid) cation radical (ABTS^+•) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH^•). Finally, biological properties of the complex studied were investigated in relation to its cytoprotective activity against the oxidative damage generated exogenously by using hydrogen peroxide in the HT22 hippocampal neuronal cell line (the MTT assay). Additionally, the biological action of the compound towards two human osteosarcoma HOS and MG-63 cell lines (the MTT and BrdU tests) as well as the untransformed human osteoblast hFOB 1.19 cell line was tested.

Antioxidant, vanadium, Cytoprotective activity, Hippocampal HT22 cells, Osteosarcoma cells

http://dx.doi.org/10.1002/zaac.201700022

onlinelibrary.wiley.com