Repozytorium
Wyszukaj
Kolekcje
Inne
Copper(II) binding to Cap43 protein fragments.
Autorzy
Rok wydania
2008
Czasopismo
Strony
6127-6134
DOI
10.1039/B808600A
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The C-terminal 20 and 30 amino acid sequences of Cap43 protein were chosen as models to study their interactions with Cu(II) ions. The behaviour of the 20 amino acid Ac–TRSRSH6TSEG–TRSRSH16TSEG and 30 amino acid Ac–TRSRSH6TSEG–TRSRSH16TSEG–TRSRSH26TSEG peptides towards Cu(II) ions at different pH values and different ligand-to-metal molar ratios, was examined. Spectroscopic (EPR, UV-Vis) and potentiometric techniques were performed to understand the details of metal binding to the peptides. The study showed that, starting from pH 4.0, each 10 amino acid fragment T1R2S3R4S5H6T7S8E9G10 was able to independently coordinate a single Cu(II) ion. The coordination mode involved the imidazole nitrogen of histidine H6 residue, and three amidic nitrogens from histidine H6, serine S5, and arginine R4 residues, respectively.
Adres publiczny
DOI https://doi.org/10.1039/B808600A
Strona internetowa wydawcy
Podobne publikacje
Nickel(II) binding to Cap43 protein fragments.
Zoroddu Maria Antonietta, Peana Massimiliano, Kowalik-Jankowska Teresa, Kozłowski Henryk, Costa Max
Interaction of Cap43 protein fragments with Ni(II) and Cu(II).
Zoroddu Maria Antonietta, Medici Serenella, Peana Massimiliano, Kowalik-Jankowska Teresa, Kozłowski Henryk
Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR.
Zoroddu Maria Antonietta, Kowalik-Jankowska Teresa, Kozłowski Henryk, Salnikow Konstantin, Costa Max