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Inne
Vinylphosphonium salt-mediated reactions: a one-pot condensation approach for the highly cis-selective synthesis of N-benzoylaziridines and the green synthesis of 1,4,2-dioxazoles as two important classes of heterocyclic compounds.
Autorzy
Rok wydania
2019
Czasopismo
Numer woluminu
21
Strony
22-26
DOI
10.1021/acs.orglett.8b03388
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
An efficient, one-pot, and convenient approach for the reaction of the same precursors, trialkyl(aryl) phosphines, acetylene diesters, and benzhydroxamic acids has been developed to produce two important classes of heterocyclic compounds: N-benzoylaziridines and 1,4,2-dioxazoles. The strategy utilizes the intermediate solvation as a key step in product selectivity. The usefulness of the developed approach has been confirmed in the unprecedented highly cis-selective formation of the N-benzoylaziridines. In addition, the procedure provides a green alternative method for the synthesis of 1,4,2-dioxazoles employing a β-cyclodextrin nanoreactor in aqueous media.
Adres publiczny
http://doi.org/10.1021/acs.orglett.8b03388