Repozytorium
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Inne
Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules.
Autorzy
Rok wydania
2021
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
217
Strony
111386/1-111386/17
DOI
10.1016/j.jinorgbio.2021.111386
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The involvement of metal ions in interactions with therapeutic peptides is inevitable. They are one of the factors able to fine-tune the biological properties of antimicrobial peptides, a promising group of drugs with one large drawback – a problematic metabolic stability. Appropriately chosen, proteolytically stable peptidomimetics seem to be a reasonable solution of the problem, and the use of D-, β-, γ-amino acids, unnatural amino acids, azapeptides, peptoids, cyclopeptides and dehydropeptides is an infinite reservoir of metal binding motifs in metabolically stable, well-designed, biologically active molecules. Below, their specific structural features, metal-chelating abilities and antimicrobial potential are discussed.
Słowa kluczowe
Peptidomimetics, Antimicrobial peptides, Metal binding sites
Adres publiczny
http://dx.doi.org/10.1016/j.jinorgbio.2021.111386
Strona internetowa wydawcy
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