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Kolekcje
Inne
Fluphenazine : from an isolated molecule to its interaction with lipid bilayers.
Autorzy
Rok wydania
2015
Czasopismo
Chemistry and Physics of Lipids
Numer woluminu
186
Strony
51-60
DOI
10.1016/j.chemphyslip.2015.01.002
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Fluphenazine (FPh) belongs to the phenothiazine family of compounds and exhibits a wide variety of biological effects, including antimutagenic, proapoptotic, antiproliferative and anti-multidrug resistance (MDR) activities. The ability of FPh to interact with lipid membranes can have a significant impact on its biological activities. However, the mechanisms involved in the interaction of FPh with lipid membranes are poorly understood. FTIR-ATR spectroscopy has been used in this study to visualize the interactions between FPh and a model lipid bilayer composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Subsequent interpretation of the temperature-dependent FTIR spectra obtained for FPh:DPPC systems containing different concentrations of FPh was efficiently supported by principal component analysis.
Słowa kluczowe
FTIR–ATR spectroscopy, Fluphenazine, Lipid film, principal component analysis
Adres publiczny
http://dx.doi.org/10.1016/j.chemphyslip.2015.01.002
Strona internetowa wydawcy
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