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Inne
1H-NMR and 13C-NMR investigation of complexes of Mn2+ with ocytocin analogues in (2H6)dimethylsulfoxide.
Autorzy
Rok wydania
1996
Czasopismo
European Journal of Biochemistry
Numer woluminu
240
Strony
118-124
DOI
10.1111/j.1432-1033.1996.0118h.x
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Several ocytocin analogues were synthesised by substitution of the Pro residue with sarcosine or N-methylalanine, the glutamine residue with threonine and one of the cysteines with 2-mercaptopropionic acid. All the derivatives were investigated by NMR in dimethylsulfoxide solutions and evidence was obtained for similar preferred conformations in the solution free state. All peptides were shown to form complexes with Mn2+ in solution by the strong paramagnetic effects experienced by several proton resonances. Two structures could be determined, one formed by peptides containing threonine and the other by the remaining peptides. The two structures were delineated by molecular modelling using the Mn2+-proton distances obtained by NMR as restraints.
Słowa kluczowe
ocytocin analogue, manganese(II), NMR, relaxation
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