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First step towards a model system of the drug delivery network based on amide-POSS nanocarriers.
Autorzy
Rok wydania
2017
Czasopismo
Numer woluminu
7
Strony
8394-8401
DOI
10.1039/c6ra26330e
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Streszczenie
Among the varied and diverse family of drug delivery systems (DDSs), such as polymer-drug conjugates,polymeric micelles, dendrimers and molecular containers, polyhedral oligomeric silsesquioxanes (POSS) occupy a special position within the group of biocompatible drug carriers. The extraordinary recommendation of POSS for such systems derives from their three-dimensional structure, nanoscale size, low toxicity, and efficient cellular uptake. These conjugates can be strictly designed compared for instance to micelles, dendrimeric-drug or polymer/inorganic hybrid composites, in which the amount of therapeutics attached to the carrier is rather random, and there is a high probability that some of the drug molecules can be completely trapped inside the ramified structures. The combination of fully functionalized amide-POSS and pharmaceuticals might create a so-called sophisticated DDS. In sucha system, the adsorbed drug molecules can be released under physiological conditions and then the POSS-based carrier will be hydrolyzed (at pH=7.40) to a non-toxic carboxylic acid salt and a watersoluble polyhedral oligomeric silsesquioxane containing an aminopropyl group that can be safely removed from the organism.
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Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode
Adres publiczny
http://dx.doi.org/10.1039/c6ra26330e