Repozytorium
Wyszukaj
Kolekcje
Inne
A 1:1 pharmaceutical cocrystal of myricetin in combination with uncommon piracetam conformer: X-ray single crystal analysis and mechanochemical synthesis.
Autorzy
Rok wydania
2014
Czasopismo
Journal of Molecular Structure
Numer woluminu
1058
Strony
114-121
DOI
10.1016/j.molstruc.2013.10.071
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Combination of two Active Pharmaceutical Ingredients, myricetin and piracetam, yields a 1:1 cocrystal characterized by X-ray single-crystal and powder diffraction, Raman spectroscopy, 1H NMR, thermal analysis (DSC and TG-DTA) methods. Constituents of the cocrystalline phase were also investigated in terms of Hirshfeld surfaces. Compounds in their neutral forms cocrystallize in the Pna21 space group of orthorhombic system. Notably, piracetam adopts an uncommon conformation, not encountered in its cocrystals previously described. In the crystal lattice, a three-dimensional hydrogen-bonded network is observed, including formation of a 2D molecular scaffolding motif. A scale-up procedure is readily available with use of solvent-drop grinding method, in which application of a variety of common solvents leads to formation of the cocrystal, as confirmed by XRPD and Raman spectroscopy.
Słowa kluczowe
Myricetin, Piracetam, Cocrystals, Solvent-drop grinding, Mechanochemistry, X-ray crystallography
Adres publiczny
http://dx.doi.org/10.1016/j.molstruc.2013.10.071
Strona internetowa wydawcy
Podobne publikacje
Solid-state characterization and solubility of a genistein-caffeine cocrystal.
Sowa Michał, Ślepokura Katarzyna, Matczak-Jon Ewa
Synthesis, spectroscopy and magnetism of fluoridoborate transition metal complexes with aminoflavone ligand (3-af). X-ray crystal structure of [Cu(BF4)2(3-af)2] and [Zn(BF4)(3-af)2](BF4)·CH3C(O)OEt.
Żurowska Bogumiła, Ślepokura Katarzyna, Fabijańska Małgorzata, Ochocki Justyn