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Inne
Iron-catalyzed arylation of aromatic ketones and aldehydes mediated by organosilanes.
Autorzy
Rok wydania
2014
Czasopismo
European Journal of Organic Chemistry
Strony
4137-4147
DOI
10.1002/ejoc.201402023
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A simple and efficient iron-catalyzed method for arylation of aromatic carbonyl compounds is reported. The use of 4 % FeCl3 or Fe(acac)3 as the catalyst, in combination with a slight excess of chlorotrimethylsilane and triethylsilane, chlorination of benzylic ketones and aldehydes with subsequent Friedel–Crafts alkylation of arenes is achieved. Although the method is limited by the general constraints associated with Friedel–Crafts alkylation reactions, robust applications for the synthesis of pharmaceutical intermediates and so on can be envisioned.
Słowa kluczowe
synthetic methods, homogeneous catalysis, Iron, silanes
Adres publiczny
http://dx.doi.org/10.1002/ejoc.201402023
Strona internetowa wydawcy
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