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Inne
Novel organotin complexes containing the 2,2'-bipyridine-3,3',6,6'-tetracarboxylate. Helical supramolecular structure and cytostatic activity.
Autorzy
Rok wydania
2015
Czasopismo
Journal of Organometallic Chemistry
Numer woluminu
777
Strony
81-87
DOI
10.1016/j.jorganchem.2014.11.027
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Reaction between 2,2′-bipyridine-3,3′,6,6′-tetracarboxylic acid (bptcH4) (1) and [Sn2Bu6O] in mild conditions proceeds with Sn-Bu bond cleavage giving polynuclear compounds. Complexes [(H2O)SnBu2(bptc)Sn2Bu6]·H2O (2), [(CH3OH)SnBu2(bptc)Sn2Bu6]·H2O (2a), [(DMF)SnBu2(bptc)Sn2Bu6] (2b) and [(DMF)SnBu2(bptc)Sn2Bu6]·0.5DMF·0.5H2O (3) were characterized using IR, NMR and ESI-MS spectroscopies. The X-ray structures of 1·H2O and (3) have been determined. Compound (3) is an exceptional polymer with seven-coordinate and five-coordinate Sn atoms. The Sn atoms are connected via screw-shaped C10H4N2(COO)4 bridges giving 3D helical network. The NMR and ESI-MS spectra reveal, that complexes in solutions dissociate giving mainly dinuclear complexes. Complex 2 interacts with adenosine 5′-monophosphate (AMP) via phosphate group. Compounds (2), (2a) and (2b) are very effective cytostatic agents against C-32, SNB-19, SH-4 and Colo-829 tumor cells.
Słowa kluczowe
Dibutyltin, tributyltin, molecule, 2′-bipyridine-3, 3′, structure elucidation, 6′-tetracarboxylate, AMP, Cytostatic activity, X-ray structure
Adres publiczny
http://dx.doi.org/10.1016/j.jorganchem.2014.11.027
Strona internetowa wydawcy
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