Repozytorium
Wyszukaj
Kolekcje
Inne
Enzymatic resolution of racemic secondary cyclic allylic alcohols.
Autorzy
Rok wydania
2010
Czasopismo
Numer woluminu
21
Strony
670-678
DOI
10.1016/j.tetasy.2010.02.031
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The resolutions of five racemic cyclic alcohols: 6,6-dimethylcyclohex-2-en-1-ol (±)-5, 4,4-dimethylcyclohex-2-en-1-ol (±)-7, 5,5-dimethylcyclohex-2-en-1-ol (±)-11 and isomeric trans-(±)-13 and cis-piperitols (±)-14 are presented. They were resolved by enzymatic esterification with vinyl esters or by enzymatic hydrolysis of their racemic esters in phosphate buffer. The following lipases were used as biocatalysts: Novozyme 435 (Candida antarctica), Amano PS (Burkholderia cepacia) and lipase from Candida cylindracea. All isomers of alcohols were obtained with at least 96% ee.
Adres publiczny
https://doi.org/10.1016/j.tetasy.2010.02.031