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Inne
Isothiocyanate ʟ−argininato copper(II) complexes : solution structure, DNA interaction, anticancer and antimicrobial activity.
Autorzy
Rok wydania
2021
Czasopismo
Chemico-Biological Interactions
Numer woluminu
348
Strony
109636/1-109636/12
DOI
10.1016/j.cbi.2021.109636
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
l−argininato copper(II) complexes have been intensively investigated in a variety of diseases due to their therapeutic potential. Here we report the results of comprehensive structural studies (ESI−MS, NIR−VIS−UV, EPR) on the complexes arising in aqueous solutions of two ternary copper(II) complexes with molecular formulas from crystal structures, [Cu(l−Arg)2(NCS)](NCS)·H2O (1) and [Cu(l−Arg)(NCS)2] (2) (l−Arg = l−arginine). Reference systems, the ternary Cu(II)/l−Arg/NCS− as well as binary Cu(II)/NCS− and Cu(II)/l−Arg, were studied in parallel in aqueous solutions by pH−potentiometric titration, EPR and VIS spectroscopy to characterize stability, structures and speciation of the formed species over the broad pH range. Comparative analysis of the obtained results showed that at a pH close to 7.0 mononuclear [Cu(l−Arg)2(NCS)]+ is the only species in water solution of 1, while equilibrium between [Cu(l−Arg)(SCN)]+ and binary [Cu(l−Arg)2]2+ was detected in water solution of 2. According to DNA binding studies, the [Cu(l−Arg)2(NCS)]+, [Cu(l−Arg)(SCN)]+ and [Cu(l−Arg)2]2+ species could be considered as strong minor groove binding agents causing, in the presence of H2O2, the involvement of ROS in plasmid damage. The human carcinoma cells (A549 cell line) were generally significantly more sensitive to cytotoxic and antiproliferative effect of compounds 1 and 2 than human normal cells. The studied compounds shown antimicrobial activity against bacteria belonging to Enterobacteriaceae family.
Słowa kluczowe
L−Arginine, Isothiocyanate ions, Potentiometric, NIR−Vis−UV and EPR spectroscopies, Free radicals, Cytotoxic and antiproliferative potential, Antimicrobial properties
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Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode
Adres publiczny
http://dx.doi.org/10.1016/j.cbi.2021.109636
Strona internetowa wydawcy
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