Repozytorium
Wyszukaj
Kolekcje
Inne
Interactions between Ni2+ ions and tetrapeptides containing (Asp/Lys)HisGly(L/D)His sequence.
Autorzy
Rok wydania
2010
Czasopismo
Numer woluminu
29
Strony
3052-3058
DOI
10.1016/j.poly.2010.08.007
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A series of linear tetrapeptides containing two histidyl residues in positions 2 and 4 with different chirality: DHGH, DHG(d-His), KHGH, KHG(d-His), Ac-DHGH-NH2, Ac-DHG(d-His)-NH2, Ac-KHGH-NH2, and Ac-KHG(d-His)-NH2 were synthesized, characterized and their binding properties towards Ni2+ were investigated. To establish the stoichiometry and the stability of the resulting Ni2+ complexes, potentiometric titrations were carried out. The coordination mode of the complexes formed was investigated by performing extensive spectroscopic analyses (UV–Vis, CD) in strict correlation with the potentiometric results. The effects of the nature of the first amino acid (Lys versus Asp) and of the N-terminal amino group acetylation were determined. A careful comparison of the Ni2+ coordination abilities of the linear peptides provides a specific insight into the impact of the chirality of the C-terminal histidine residue (His4) on the metal binding properties.
Słowa kluczowe
Peptides, histidyl residue, chirality, nickel ions, bioinorganic chemistry
Adres publiczny
https://doi.org/10.1016/j.poly.2010.08.007
Strona internetowa wydawcy
Podobne publikacje
Coupled oxidation of heme without pyridine. Formation of cyano complexes of iron oxophlorin and 5-oxaporphyrin (Verdoheme) from octaethylheme.
Balch Alan L., Koerner R., Latos-Grażyński Lechosław, Lewis J. E., Claire T. N. St., Zovinka E. P.
The Beauty and Simplicity of the Complex Biological Chemistry of Metals
Rowińska-Żyrek Magdalena
Essential metals in medicine : therapeutic use and toxicity of metal ions in the clinic.
Gumienna-Kontecka Elżbieta
