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Self-synthesizing models of helical proteins based on aromatic disulfide chemistry.
Autorzy
Rok wydania
2018
Czasopismo
Numer woluminu
24
Strony
12869-12878
DOI
10.1002/chem.201800187
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A new method of synthesis of peptide conjugates with aromatic moieties substituted with two sulfhydryl groups at 1,3‐positions is proposed. Amphiphilic peptides derivatized in such a way under oxidative conditions spontaneously form cyclic, covalent trimers and tetramers dominated by α‐helical conformations. The tendency to form tri‐ or tetrahelical bundles depends on sequences of the peptides and on the oxidation conditions, pH, and additives.
Słowa kluczowe
combinatorial chemistry, helical structures, peptides, self-assembly, template synthesis
Adres publiczny
http://dx.doi.org/10.1002/chem.201800187
Strona internetowa wydawcy
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