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Inne
Interactions of dihydrochloride fluphenazine with DPPC liposomes: ATR-IR and 31P NMR studies.
Autorzy
Rok wydania
2009
Czasopismo
Journal of Physical Chemistry B
Numer woluminu
113
Strony
15495-15502
DOI
10.1021/jp904805t
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The influence of dihydrochloride fluphenazine (FPh) on the dipalmitoylphosphatidylcholine (DPPC) bilayer structure was investigated using ATR-IR and 31P NMR methods. The ATR-IR results indicate an increase in conformational disorder in the hydrophobic part compared with pure DPPC liposomes and a decrease in temperature of the chain-melting phase transition in FPh/DPPC liposomes. These effects depended on the concentration of the drug in the DPPC bilayer. The dihydrochloride fluphenazine molecules form H-bonds with the proton-acceptor carbonyl groups of DPPC molecules. At a higher concentration of the drug, the lipid bilayer structure is destroyed, and an isotropic phase is observed using 31P NMR spectroscopy. The interactions between FPh and the lipid bilayer have a crucial role in MDR (multidrug-resistant) activity of this drug. These results improve one possible strategy of cancer chemoprevention with FPh accompanied by fluidization and destabilization of the model lipid bilayer structure.
Adres publiczny
https://doi.org/10.1021/jp904805t
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