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Inne
The unusual behavior of the inhibitor S(+)(1-amino-2-phenylethyl)phosphonic acid towards carboxypeptidase A.
Autorzy
Rok wydania
1990
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
40
Strony
227-235
DOI
10.1016/0162-0134(90)80056-4
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The molecule (1-Amino-2-phenylethyl)phosphonic acid is shown to inhibit the enzymatic activity of carboxypeptidase A. Through the spectroscopic investigation of the cobalt(II) substituted enzyme we propose that it binds the enzyme in the 1:1 ratio directly at the metal, probably through the phosphate group like phosphate itself. The aromatic group is proposed to sit in the so-called S1 hydrophobic pocket. This is a unique behavior among the inhibitors of the enzyme. The S′1 site is still available in the binary adduct so that a ternary complex can be obtained with molecules like L-Phenylalanine, which enter that site.
Adres publiczny
https://doi.org/10.1016/0162-0134(90)80056-4
Strona internetowa wydawcy
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