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Inne
Sodium sulfide promoted synthesis of highly substituted pyridines
Autorzy
Rok wydania
2025
Czasopismo
Phosphorus, Sulfur, and Silicon and the Related Elements
Numer woluminu
200
Strony
1078-1083
DOI
10.1080/10426507.2025.2571645
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
This study presents a straightforward and effective method for the synthesis of 2-amino-6-alkoxy-4-arylpyridine-3,5-dicarbonitrile derivatives. These multi-substituted pyridine compounds are prepared through a convenient pseudo three-component reaction involving arylaldehydes malononitrile, alcohols, and sodium sulfide in an aqueous medium. Key benefits of this approach include its environmentally friendly nature, high product yields, rapid reaction times, cost-effectiveness, and easy accessibility of starting materials, mild reaction conditions, and a simple purification process.
Słowa kluczowe
sodium sulfide, X-ray, pyridine, malononitrille, green chemistry
Adres publiczny
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