Repozytorium
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Kolekcje
Inne
Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering.
Autorzy
Rok wydania
2019
Czasopismo
Materials Science and Engineering C-Materials for Biological Applications
Numer woluminu
94
Strony
516-523
DOI
10.1016/j.msec.2018.09.062
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Bioactive glass-based scaffolds are commonly used in bone tissue engineering due to their biocompatibility, mechanical strength and adequate porous structure. However, their hydrophobicity and brittleness limits their practical application. In this study, to improve nanomechanical properties of such scaffolds, pure bioactive hybrid glass and two bioactive hybrid glass-polymer coated composites were fabricated. A complementary micro and nanoscale characterization techniques (SEM, AFM, μCT, FTIR, compressive test, goniometer) were implemented for detailed description of architecture and physicochemical properties of hybrid bioactive glass-based scaffolds with emphasis on nano-mechanics. The final step was in-vitro evaluation of three dimensional macroporous structures. Our findings show that after polymer addition, architecture, topography and surface properties of the scaffolds were changed and promoted favoured behaviour of the cells.
Słowa kluczowe
Tissue engineering, Scaffold, Bioactive glass, Mechanical properties
Adres publiczny
http://dx.doi.org/10.1016/j.msec.2018.09.062
Strona internetowa wydawcy
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