Repozytorium
Wyszukaj
Kolekcje
Inne
Hexaamminecobalt(III) - probing metal ion binding sites in nucleic acids by NMR spectroscopy.
Autorzy
Rok wydania
2013
Czasopismo
Zeitschrift für Anorganische und Allgemeine Chemie
Numer woluminu
639
Strony
1313-1320
DOI
10.1002/zaac.201300123
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Hexaamminecobalt(III), an octahedral, inert metal ion complex, has lately gained increasing attention of structural biologists and bioinorganic chemists due to its use in structure determination of nucleic acids. This complex mimics outer‐sphere binding events of the physiologically relevant magnesium(II)hexaaqua ion; hexaamminecobalt(III) often finds usage either in NMR spectroscopy, where cross‐peaks between the complex ammines and the nucleic acid protons near the binding site are observed, in X‐ray spectroscopy as heavy metal derivative for phasing, or in other techniques. In this review, we discuss the basic hexaamminecobalt(III) binding modes and give an overview on the most recent findings on [Co(NH3)6]Cl3–nucleic acid complexes. The various techniques that are applied in combination with this complex are mentioned and briefly summarized. Special attention is given to the application of [Co(NH3)6]Cl3 in nuclear magnetic resonance spectroscopy of nucleic acids, where it is used to reveal potential outer‐sphere magnesium binding sites.
Słowa kluczowe
Hexaamminecobalt(III), Nucleic acids, NMR spectroscopy, Metal ions
Adres publiczny
http://dx.doi.org/10.1002/zaac.201300123
Strona internetowa wydawcy
Podobne publikacje
Effect of selected organic materials on soil humic acids chemical properties.
Pospíšilová Lubica, Horáková Eva, Fišera Miroslav, Jerzykiewicz Maria, Menšik Ladislav
NMR investigations of metal interactions with unstructured soluble protein domains.
de Ricco Riccardo, Potocki Sławomir, Kozłowski Henryk, Valensin Daniela
Impact of Cu(II)n and Ni(II) on a structure of chiral peptide nucleic acids having four, six and eight thymines in a peptide side chain.
Brasuń Justyna, Ołdziej S., Taddei M., Kozłowski Henryk