Repozytorium
Wyszukaj
Kolekcje
Inne
Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A.
Autorzy
Rok wydania
1993
Czasopismo
Archivum Immunologiae et Therapiae Experimentalis
Numer woluminu
41
Strony
285-289
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
We demonstrated that a linear peptide Gly-Ile-Ile-Leu-Val-Pro-Pro-Phe, the analog of a cyclic nonapeptide c-(Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-Phe) possesses a distinct immunosuppressive activity. We synthesized a series of eight other analogs of the linear peptide. The series consists of the nonapeptides protected on N- and/or C-terminus by acetyl-, succinyl-, and amido- functions and of Gly-Ile-Ile-Leu-Val-Pro-Pro-Phe-Phe elongated on N- and/or C-terminus by additional glycine residues. It was found that the protection of the terminal functional groups of the peptide slightly increases its immunosuppressor potency. At the same time the elongation of the peptide chain on both termini by additional glycine residues evokes a distinct increase of the immunosuppressive activity.
Strona internetowa wydawcy
Podobne publikacje
Immunosuppressive activity of cyclolinopeptide A analogs.
Siemion Ignacy Z., Bengtsson B., Trojnar J., Pędyczak Artur, Cebrat Marek, Zimecki Michał, Wieczorek Zbigniew
Immunosuppressive activity of alanine analogs of cyclolinopeptide A.
Wieczorek Zbigniew, Zimecki Michał, Pędyczak Artur, Lisowski Marek, Siemion Ignacy Z.
Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A.
Siemion Ignacy Z., Cebrat Marek, Lisowski Marek, Zimecki Michał, Wieczorek Zbigniew