Repozytorium
Wyszukaj
Kolekcje
Inne
Role of sulfur site in metal binding to thiopurine and thiopyrimidine nucleosides.
Autorzy
Rok wydania
1997
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
65
Strony
257-262
DOI
10.1016/S0162-0134(96)00140-7
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Thiolation of uridine and purine bases leads to the formation of very effective ligands for Cd(II) and Ni(II) ions. Potentiometric and spectroscopic studies have shown that the substitution of oxygen by sulfur in uridine, which is a poor ligand for most metal ions, allows thiouridine to strongly bind both Cd(II) and Ni(II) ions. The {N, S} chelation is observed for thiopurines and thiouridines, even if the {S, N(3)} chelation in uridine derivatives leads to the formation of a thermodynamically unfavorable four-member chelate ring. Metal complexes with thiopurine with a five-member chelate ring are, however, considerably more stable (up to 3.5 orders of magnitude) than those of thiouridines.
Adres publiczny
https://doi.org/10.1016/S0162-0134(96)00140-7
Strona internetowa wydawcy
Podobne publikacje
Extent of metal ion-sulfur binding in complexs of thiouracil nucleosides and nucleotides in aqueous solution.
Odani A., Kozłowski Henryk, Świątek-Kozłowska Jolanta, Brasuń Justyna, Operschall B. P., Sigel Helmut
Determination of the role of specific amino acids in the binding of Zn(II), Ni(II), and Cu(II) to the active site of the M10 family metallopeptidase
Potok Paulina, Zawada Martyna, Potocki Sławomir
Thermodynamic and spectroscopic investigation on the role of met residues in CuII binding to the non-octarepeat site of the human prion protein.
Remelli Maurizio, Valensin Daniela, Toso Leonardo, Gralka Ewa K., Guerrini Remo, Marzola Erika, Kozłowski Henryk