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Inne
Iron(III) and aluminum(III) complexes with hydroxypyrone ligands aimed to design kojic acid derivatives with new perspectives.
Autorzy
Rok wydania
2010
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
104
Strony
560-569
DOI
10.1016/j.jinorgbio.2010.01.007
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
With the aim to design new chelators for the clinical treatment of different diseases involving the trivalent metal ions Fe(III) and Al(III), we present the equilibria of kojic acid and its derivative 6-[5-hydroxy-2-hydroxymethyl-pyran-4-one]-5-hydroxy-2-hydroxymethyl-pyran-4-one with these two metal ions. Potentiometric and spectrophotometric techniques for iron, and potentiometry and 1H NMR for aluminum were used, supported by X-ray, electrospray ionization-mass spectrometry (ESI-MS), calorimetry and quantum chemical calculations. In this work, evidence is given on the formation of MeL, MeL2, and MeL3 complexes of both metal ions with kojic acid, confirmed by the X-ray structure of the FeL3 complex, and of variously protonated Me2L2 and MeL2 complexes of 6-[5-hydroxy-2-hydroxymethyl-pyran-4-one]-5-hydroxy-2-hydroxymethyl-pyran-4-one. The extremely good pFe value for this second ligand gives confidence to, and opens perspectives for, the search of new kojic acid derivatives.
Słowa kluczowe
Kojic acid, Fe(III), Al(III), pFe, Solution equilibria, Thermodynamic measurements, X-ray structure, molecular modeling, synthesis
Adres publiczny
https://doi.org/10.1016/j.jinorgbio.2010.01.007
Strona internetowa wydawcy
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