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Hydrogen scrambling in non-covalent complexes of peptides.
Autorzy
Rok wydania
2012
Czasopismo
Rapid Communications in Mass Spectrometry
Numer woluminu
26
Strony
2739-2744
DOI
10.1002/rcm.6396
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Mass spectrometry analysis combined with hydrogen-deuterium exchange (HDX-MS) is arising as a tool for quick analysis of native protein conformation. However, during collision-induced dissociation (CID) the spatial distribution of deuterium is not always conserved. It is therefore important to find out how hydrogen scrambling occurs--this study concentrates on the possibility of scrambling between amino acid residues spatially close together, but not connected by covalent bonds.
Adres publiczny
htpp://doi.org/10.1002/rcm.6396
Strona internetowa wydawcy
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