Repozytorium
Wyszukaj
Kolekcje
Inne
Diorganotin complexes of a thiosemicarbazone, synthesis: properties, X-ray crystal structure, and antiproliferative activity of diorganotin complexes.
Autorzy
Rok wydania
2010
Czasopismo
Bioinorganic Chemistry and Applications
Strony
867195/1-867195/9
DOI
10.1155/2010/867195
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Streszczenie
The synthesis and spectral characterization of novel diorganotin complexes with 3-hydroxypyridine-2-carbaldehyde thiosemicarbazone, H2L (1), [SnMe2(L)] (2), [SnBu2(L)] (3), and [SnPh2(L)] (4) are reported. The single-crystal X-ray structure of complex [SnPh2(L)(DMSO)] (5) shows that the ligand is doubly deprotonated and is coordinated as tridentate ligand. The six coordination number is completed by two carbon atoms of phenyl groups. There are two similar monomers 5a (Sn1) and 5b (Sn51) in the asymmetric unit. The monomers 5a and 5b are linked through intermolecular hydrogen bonds of N–H–O and C–H–S type. C–H → π, intermolecular interactions, intra- and intermolecular hydrogen bonds stabilize this structure and leads to aggregation and a supramolecular assembly. The IR and NMR (1H, 13C and 119Sn) spectroscopic data of the complexes are reported. The in vitro cytotoxic activity has been evaluated against the cells of three human cancer cell lines: MCF-7 (human breast cancer cell line), T-24 (bladder cancer cell line), A-549 (nonsmall cell lung carcinoma) and a mouse L-929 (a fibroblast-like cell line cloned from strain L). Compounds 1, 3, and 4 were found active against all four cell lines. Selectivity was observed for complexes 3 and 4 which were found especially active against MCF-7 and T-24 cancer cell lines.
Licencja otwartego dostępu
Licencja na prawach której można swobodnie kopiować, rozprowadzać, zmieniać i remiksować objęty prawem autorskim utwór (Utwór-przedmiot prawa autorskiego) pod warunkiem podania imienia i nazwiska autora utworu pierwotnego oraz źródła pochodzenia utworu.
Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode
Adres publiczny
Podobne publikacje
Organotin complexes of pyruvic acid thiosemicarbazone: synthesis, crystal structures and antiproliferactive activity of neutral and cationic diorganotin complexes.
Wiecek Joanna, Dokorou V., Ciunik Zbigniew, Kovala-Demertzi Dimitra
Pseudohalide manganese(II) complexes of 2-hydroxymethylbenzimidazole - synthesis, spectroscopy, X-ray structure and magnetic properties.
Palion-Gazda Joanna, Machura Barbara, Klemens T., Kłak Julia
Hybrid inorganic-organic complexes : synthesis, spectroscopic characterization, single crystal X-ray structure determination and antimicrobial activities of three copper(II)-diethylenetriamine-p-nitrobenzoate complexes.
Kumar Santosh, Sharma Raj Pal, Venugopalan Paloth, Gondil Vijay Singh, Chhibber Sanjay, Aree Thammarat, Witwicki Maciej, Ferretti Valeria