Wydział Chemii

Justyna Brasuń

Marek Cebrat

Łukasz Jaremko

Mariusz Jaremko

G. Ilc

Olimpia Gładysz

Igor Zhukov

2009

Dalton Transactions

4853-4857

10.1039/b901676g

Naukowa

Angielski

Artykuł

A replacement of both Cys residues by His in oxytocin (OXT) sequence allows for the formation of the stable complex with the {NH₂, N_Im, N_{Im(macrochelate)}} binding mode at the physiological pH. The detailed potentiometric and spectroscopic studies on the Cu(II) complexes of [His^1,6]OXT, together with high resolution NMR investigations on 3D structures of Cu(II) complexes with [His^1,6]OXT and [His^1,6]AVP analogues are presented and discussed. Exchange of the Cys-S-S-Cys bridge by the His-Cu(II)-His motif is very promising, because the resulting complexes retain topological similarity to the native S–S bridged AVP and OXT at pH values corresponding to the physiological pH.

https://doi.org/10.1039/b901676g

https://www.rsc.org/