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Solid solutions of quasi-isomorphous diastereomeric salts - kinetics versus thermodynamics.
Autorzy
Rok wydania
2013
Czasopismo
Numer woluminu
15
Strony
5681-5687
DOI
10.1039/c3ce40512e
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Attempts of racemic resolution by a fractional crystallization of diastereomeric salts of enantiopure resolving agent very often leads to precipitation of solid solutions with different ratios of both diastereomeric salts. Structural investigations of solid solutions can be helpful for a better understanding of the chiral discrimination mechanism which is useful for the rationalization of optical resolution. Based on the crystal structures of a few related solid solutions of brucinium diastereomeric salts and the corresponding diastereomeric salts factors influencing the kinetics and thermodynamics on the molecular recognition leading to the solid solution formation are proposed.
Adres publiczny
http://dx.doi.org/10.1039/c3ce40512e