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Inne
Copper (II) complexes of deltakephalin and its analogues containing α-hydroxymethylserine.
Autorzy
Rok wydania
2000
Czasopismo
Numer woluminu
19
Strony
241-245
DOI
10.1016/S0277-5387(99)00377-0
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Potentiometric and spectroscopic data have shown that deltakephalin and its derivatives containing the α-hydroxymethylserine (HmS) residue in the second and in the second and sixth positions form the same series of complexes: CuHL, CuL, CuH−1L, CuH−2L and CuH−3L (1N to 4N binding mode). The alcoholic groups in the amino acid side chain are very effective in the stabilization of the complexes formed (the protonation corrected stability constants, log K*, values of 4N complexes are −22.55 and −21.15 for deltakephalin and its derivative containing the HmS residue in the second and sixth positions, respectively). There is no evidence for the direct involvement of alcoholic groups of HmS in binding of Cu2+ ions and there is no indication of binding through the tyrosine-phenolate oxygen atoms, either.
Adres publiczny
https://doi.org/10.1016/S0277-5387(99)00377-0
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