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Suzuki—Miyaura cross-coupling of N-acylpyrroles and pyrazoles : planar, elecronically activated amides in catalytic N—C cleavage.
Autorzy
Rok wydania
2017
Czasopismo
Numer woluminu
19
Strony
3596-3599
DOI
10.1021/acs.orglett.7b01575
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The formation of C–C bonds from amides by catalytic activation of the amide bond has been thus far possible by steric distortion. Herein, we report the first example of a general Pd-catalyzed Suzuki–Miyaura cross-coupling of planar amides enabled by the combination of (i) electronic-activation of the amide nitrogen in N-acylpyrroles and pyrazoles and (ii) the use of a versatile Pd-NHC catalysis platform. The origin and selectivity of forming acylmetals, including the role of twist, are discussed.
Adres publiczny
http://dx.doi.org/10.1021/acs.orglett.7b01575
Strona internetowa wydawcy
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