Repozytorium
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Kolekcje
Inne
Impact of Cu2+ ions on the structure of colistin and cell-free system nucleic acid degradation.
Autorzy
Rok wydania
2015
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
151
Strony
67-74
DOI
10.1016/j.jinorgbio.2015.05.011
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Colistin and transition metal ions are commonly used as feed additives for livestock animals. This work presents the results of an analysis of combined potentiometric and spectroscopic (UV–vis, EPR, CD, NMR) data which lead to conclude that colistin is able to effectively chelate copper(II) ions. In cell-free system the oxidative activity of the complex manifests itself in the plasmid DNA destruction with simultaneous generation of reactive OH species, when accompanied by hydrogen peroxide or ascorbic acid. The degradation of RNA occurs most likely via a hydrolytic mechanism not only for complexed compound but also colistin alone. Therefore, huge amounts of the used antibiotic for nontherapeutic purposes might have a potential influence on livestock health.
Słowa kluczowe
colistin, copper(II) complex, DNA and RNA degradation, Oxidative and hydrolytic properties
Adres publiczny
http://dx.doi.org/10.1016/j.jinorgbio.2015.05.011
Strona internetowa wydawcy
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